In this randomized, double-blinded, placebo-controlled interventional trial of healthy human adults, we investigated the clinical and molecular immunomodulatory effects of a single high dose of oral vitamin D3 on an experimentally induced chemical rash.METHODS Skin inflammation was induced with topical nitrogen mustard (NM) in 28 participants. Systemically administered cholecalciferol (vitamin D3) has immunomodulatory properties. The product is suitable for vegans and vegetarians.BACKGROUND Adverse drug reactions are unpredictable immunologic events presenting frequent challenges to clinical management.

Cholecalciferol is converted in the body to the active ingredient calcitriol. In combination with calcium, it is used against osteoporosis. It is used as a mono-preparation to prevent and treat vitamin D deficiency. Cholecalciferol (also known as colecalciferol or calciol for short) is the main physiological form of vitamin D in humans. Cholecalciferol is the precursor of active vitamin D, which plays a central role in the regulation of calcium and phosphate metabolism.Activation of vitamin D3 occurs in the liver, and further conversion to calcitriol occurs in the kidney. Vitamin D3, also called cholecalciferol, is the form of vitamin D that our skin synthesizes from cholesterol when exposed to the sun (UV-B). Burgerstein D3 liquid does not contain alcohol. Children need vitamin D3 for healthy growth and bone development. Muscle function and the immune system also need vitamin D3 in a sufficient quantity. Vitamin D3 contributes to the absorption and utilization of calcium and the maintenance of normal bone mass. Vitamin D3 spray replaces the well-known vitamin D3 liquid (600 IU) since December 2020. The tasteless spray, based on coconut oil, is of course alcohol-free and therefore also ideal for children. Burgerstein Vitamin D3 spray contains vitamin D3 in the form of the easily metabolizable cholecalciferol.

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